How could He have sweated blood? It is a condition known as hematohidrosis. Jesus was in agony over something that He specified. Not the pain, not the suffering, not the jeering crowds or the traitorous companion but "this cup" was on His mind. I have asked the question before, "why did Jesus suffer" in the Garden and blogged an answer. But come with me to that question of the cup. There is an oft-mentioned cup in the Old Testament that is the cup of sin and shame and the wrath of God. A few examples are listed below:
Jesus knew about the cup of shame and sin and fury and trembling and wrath - He knew that on the cross He would be forced to drink that cup. He would take upon Himself all the sins and all the shame of all men for all time and God would turn His face away from His Son and...Jesus would experience separation from God.
Separation from God. It was the one thing above all things that was unthinkable. For all time and before all time the Son the Father the Spirit were in constant harmony and companionship and had been Love and Light and nothing but Good and Truth. Now Jesus would have to become the very thing He detested above all else - Sin - and because He would become sin the Father would turn away and the Holy Spirit of God would leave Him and Jesus the Son of God would be alone. I believe it was this cup that Jesus sought to avoid and not the pain and suffering and death. I believe that Jesus would die a thousand deaths and suffer thousands of beatings rather than to become sin and be separate from God.
But He was obedient and did as the 22nd Psalms had predicted: